Development and Characterization of Bamboo yarn Knitted Wound care dressing coated with Aloe Vera Rind Nanoparticle and Enhanced with rhEGF

Abstract

The demands for natural based wound healing dressing are more in need during these days. There is also a room to improve upon currently on the market as it is either lacks the degradation and/or slow in healing practice. In this research work bamboo yarn have been used to produce single jersey knitted fabric with three variable stitch length. Next the bulk sized aloe Vera is converted to nano size by mechanical grinding method. Then the developed knitted samples are coated with nano sized aloe Vera. After coating the developed samples are loaded with drug (Epidermal Growth Factor). Scanning electronic microscope (SEM) was used to observe the morphology of developed wound dressing for process versatility and the highly specific surface area. Knitted samples loaded with rhEGF were applied over the wound surface and the wound closure was studied in equal interval of days. The formation of zone of inhibition in antibacterial test and wound closure rate in In Vivo evaluation reveals that a specified composition of natural extracts of aloe vera enhanced with rhEGF reveals that coated fabric samples exhibits good antibacterial property and higher rate of wound healing nature. Hence therefore these coated fabrics can be suitable for faster wound healing process. It offers a very attractive opportunity for producing a variety of medical products with great potential for bio medical end uses due to its superior biocompatibility.